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Three-parent children | Notes from Planet Earth

It is now possible for a child to have three parents: One parent, a male, contributing half of a full nuclear genome via a sperm by means of in vitro fertilization, the second parent, a female, contributing the other half of a full nuclear genome using just the cell nucleus from one of her egg cells. The third “surrogate parent,” also a female, contributes an egg cell that has had its nucleus removed but retains those vital subcellular organelles, the mitochondria, in the cytoplasm of her egg cell. These organelles have their own genome and replicate inside most of our cells. Normally, we inherit them only from our mothers via her egg cell’s cytoplasm.

Why would anyone want to do this? There are rare but devastating genetic disorders caused by mutations in the DNA of the female parent’s mitochondria which are the organelles responsible for our body’s ability to turn food into energy. Sperm from the male parent carry a couple of mitochondria which are needed to propel the sperm on its journey but which do not enter the female parent’s egg at the time of fertilization. Mito and Tracker were the first scientists to raise rhesus monkeys who had had the mitochondria in their mother’s egg cells replaced with those from another female. These three-parent monkeys will reach the breeding age of 5 later this year and they will be bred to see if their offspring suffer any unusual disorders that might have resulted from their unusual parentage.

Use of this complicated procedure in humans is currently outlawed in the United Kingdom. Nevertheless, the U. K. government has already issued draft regulations that would allow medical scientists to try this technique with parents in cases where the mother was known to have mitochondria carrying a serious genetic defect. The procedure would break a longstanding cultural and legal barrier to any genetic engineering in humans that would result in heritable genetic changes - that is genetic changes that will likely be passed on to both the male and female progeny of persons who had come from three parents. Up to now genetic engineering in humans has been limited to inducing changes in the non-reproductive organs, such as bone marrow, the blood forming organ, of individuals with genetic disorders that impair the functioning of this single organ.

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