O'Donnell added the doors of opportunity were now wide open for the graduates.
"Whatever you do, decide to challenge yourself, but don't forget to enjoy the journey," she said. "I hope that you will not lose sight of your values - keep your family close and your faith strong."
She said character, developed with community support, would propel the graduates toward success in their lives.
"Face your challenges with confidence and determination," O'Donnell explained. "Never doubt your ability, as you all have great potential."
In a 15-minute video presentation, featuring photos of class trips, sports events and activities, the grads and audience witnessed memorable times that conveyed the close bond shared by friends, relatives and community members.
The senior music students sang "Happy Endings," accompanied by school music teacher James Miller on guitar and O'Donnell on piano.
Adhering to school tradition, the graduates individually presented their parents with roses.
In his closing tribute to the Class of 2010, school superintendent Ray Ciccarelli Jr. said the class had been a close one.
"You've learned the power of togetherness," he said. "Our world will always yearn for more of that."
Ciccarelli noted the phrase from the school alma mater, "Always loyal, always faithful we will be to you," may have once referred to students remaining loyalty to the community, but from now forward it means the community will be loyal to the graduates.
As he introduced the Class of 2010 formally, the audience responded with robust cheers and gave the graduates a standing ovation.